AROA ECM regenerates functional tissue14,15,24
Optimal Structure & Biology
Natural porous ECM with signaling, cell recruitment and anti-inflammatory proteins9,12
Angioconductive
Dense network of residual vascular channels advances revascularization10
Orchestrates Regeneration
Facilitates stem cell recruitment & directs tissue growth through constructive remodeling15,24,25
AROA ECM
Retains the native tissue structure
- Gentle processing removes unwanted cellular material to avoid an inflammatory response20
- Provides an intact porous scaffold for tissue infill20
Rich in biology
- Contains >150 ECM proteins including growth factors, signaling and anti-inflammatory proteins9
Modulate wound inflammatory proteins and assists in hemostasis
Supports advancement of epithelial and endothelial tissue
Proteins known to support cell adhesion, as well as maintenance and repair
Signaling factors that mediate cell communication during tissue repair and remodeling
Diverse collagens and structural proteins that perform a wide array of functions in soft tissue repair and remodeling
| Structural proteins |
|---|
| 17 Collagens (incl I, III, IV, V & VII) Laminin and Elastin |
| ECM Regulators |
|---|
| Coagulation factors and Protease Inhibitors |
| Growth factors |
|---|
| Fibroblast Growth Factor (FGF), Platelet-Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) |
| Basement membrane |
|---|
| Collagen IV, Laminen, Perlecan |
| Glycoproteins |
|---|
| Laminin, Fibronectin and Decorin |
Angioconductive
- Residual vascular channels template new blood vessels10
- Facilitates rapid vascularization10
- New vasculature nourishes regenerating tissue10
Orchestrates regeneration
The AROA ECM:
- Facilitates stem cell recruitment24
- Is infiltrated by the patients' cells25
- Is incorporated and remodeled into robust functional tissue24,25
Pre-operative assessment
Fully epithelialized with hair growth
