Application in Calciphylaxis

Symphony™

Basil Z. Khalaf, M.D.

Medical Director, MEDiKAL VIP Medical Concierge Services, Houston, TX, USA
Initial Presentation
Week 5 – Healed

Results

  • Fully epithelialized after 5 Weeks
  • Only two applications of Symphony
  • Pliable functional tissue regenerated
  • No pain
  • No complications or recurrence as at 6-months

Patient details

42-year-old male

Medical history

  • ESRD, peripheral vascular disease

Case details

  • Patient developed large painful irregular fibro-necrotic ulceration of the forearm for 3 weeks prior to Symphony treatment
  • Initially treated with antibiotics and local wound care

Application photos

Initial Presentation

  • Wound debrided and Symphony hydrated and applied to wound, trimmed to size, and secured with Steri-Strips™

Week 1

  • Symphony well integrated with significant development of viable granulation tissue
  • Pain significantly improved

Week 4

  • Second Symphony application at week 2
  • Further development of robust granulation tissue and significant epithelialization noted
  • Pain nearly eradicated

Week 5 - Healed

  • Fully epithelialized
  • Pliable functional tissue regenerated
  • No pain
  • Two applications of Symphony
  • No complications nor recurrence as of 6-months

Results may vary. Dr. Basil Z. Khalaf has a consultancy agreement with Aroa Biosurgery.
Steri-Strip™ is a trademark and property of the respective owner.

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  1. Lawlor et al (2024). Plastic and Reconstructive Surgery – Global Open 12(12): e6406
  2. Cormican et al (2023). ePlasty 23: e66
  3. Bosque et al (2023). J Am Podiatr Med Assoc 113(3): 22-081
  4. Taarea et al (2014). Trauma Cases Rev 10(1): 102
  5. Chaffin et al (2021). J Wound Care 30(Sup7): S28-S34
  6. Chaffin et al (2020). J Wound Care 29(11):624-630
  7. Bohn et al (2020). J Wound Care 29(12): 742-749
  8. Tsu et al (2020). Oral and Maxillofacial Surgery Cases 10(3): 100369
  9. Dempsey et al (2019). Proteome Res 18(4): 1657-1668
  10. Smith et al (2021). J Biomater Appl 36(6): 996-1010
  11. Desvigne et al (2021). Front Surg 7: 559450
  12. Negron et al (2014). Int Wound J 11(4): 392-397
  13. Data on file
  14. Overbeck et al (2020). Hernia. 24(6):1293-1306
  15. Irvine et al (2011). Biomaterials. 32(27):6351-6361

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